Development and Validation of an Integrative Risk Score for Future Risk of Crohn’s Disease in Healthy First-Degree Relatives: A Multicenter Prospective Cohort Study
Sun-Ho Lee, Williams Turpin, Osvaldo Espin-Garcia, Wei Xu, Kenneth Croitoru, Kenneth Croitoru, Sun-Ho Lee, Williams Turpin, Osvaldo Espin-Garcia, Wei Xu, Haim Leibovitzh, Mingyue Xue, Juan Antonio Raygoza Garay, Lucía Graña-Miraglia, Michelle I. Smith, Ashleigh Goethel, Karen L. Madsen, Irit Avni-Biron, Iris Dotan, Batia Weiss, Remo Panaccione, Hien Huynh, Kevan Jacobson, Guy Aumais, David Mack, Anne M. Griffiths, A. Hillary Steinhart, Mark S. Silverberg, Dan Turner, Charles N. Bernstein, Brian G. Feagan, Paul Moayyedi, Andrew Paterson, David S. Guttman, Maria Abreu, Paul Beck, Leo Dieleman, Gilaad Kaplan, Denis O. Krause, John Marshall, Mark Ropeleski, Ernest Seidman, Scott Snapper, Andy Stadnyk, Michael Surette, Thomas Walters, Bruce Vallance, Alain Bitton, Maria Cino, Jeff Critch, Lee Denson, Colette Deslandres, Wael El-Matary, Hans Herfarth, Peter Higgins, Jeff Hyams, Jerry McGrath, Anthony Otley, Kenneth Croitoru, Kenneth Croitoru
Abstract
Despite advances in medical therapy, approximately one-half of patients with Crohn’s disease (CD) develop complications ultimately requiring surgery. Currently, no treatment offers a chance of cure.1,2 The increasing incidence and prevalence of CD globally pose a substantial burden at the population and individual levels. Thus, a better understanding of the early triggers of CD is desperately needed to enhance early detection, improve medical therapy, and offer a possibility of interventions that prevent development of CD.