<i>Melissa officinalis</i>Extract Induces Apoptosis and Inhibits Migration in Human Colorectal Cancer Cells
Tzu‐Ting Kuo, Hsin‐Yi Chang, Tai‐Yuan Chen, Bai-Chia Liu, Hsin‐Yi Chen, Yuan-Chin Hsiung, Shih‐Min Hsia, Chun–Ju Chang, Tsui‐Chin Huang
Abstract
/M phase, triggered caspase-dependent apoptotic cell death, and inhibited cell migration ability by modulating the epithelial-mesenchymal transition in HCT116 CRC cells. To examine the metabolite composition in the MO hot water extract, we applied mass spectrometry-based analysis and identified 67 compounds. Among them, the phenolic compounds, including lignans, phenylpropanoids, and polyketides, are widely found in natural products and possess various bioactivities such as anti-inflammatory, antioxidation, and anticancer effects. The results indicate that herbal tea consumption benefits CRC prevention and management.