Synthesis and <i>In Vivo</i> Evaluation of a Site-specifically Labeled Radioimmunoconjugate for Dual-Modal (PET/NIRF) Imaging of MT1-MMP in Sarcomas
Toni A. Pringle, Corey D. Chan, Saimir Luli, Helen J. Blair, Kenneth S. Rankin, James C. Knight
Abstract
Zr]Zr-DFO-anti-MT1-MMP-IRDye800CW is a promising dual-modal sarcoma imaging agent for pre-operative surgical planning and intraoperative surgical guidance.
Topics & Concepts
ChemistryIn vivoImmunoconjugatePositron emission tomographyMatrix metalloproteinaseSarcomaEx vivoHT1080Imaging agentBiodistributionCancer researchNuclear medicinePathologyMedicineIn vitroMonoclonal antibodyBiochemistryImmunologyAntibodyBiologyBiotechnologyPeptidase Inhibition and AnalysisProtease and Inhibitor MechanismsSarcoma Diagnosis and Treatment