NLRP3 Exacerbate NETosis-Associated Neuroinflammation in an LPS-Induced Inflamed Brain
Da Jeong Byun, Jaeho Lee, Je‐Wook Yu, Young‐Min Hyun
Abstract
and in the inflamed brain, aggravating neuroinflammation. These findings provide a clue that NLRP3 would be a potential therapeutic target to alleviate neuroinflammation.
Topics & Concepts
Neutrophil extracellular trapsNeuroinflammationInflammationInnate immune systemBlood–brain barrierImmune systemMicrogliaImmunologyProgrammed cell deathMedicineBrain damageCell biologyBiologyApoptosisInternal medicineCentral nervous systemBiochemistryNeutrophil, Myeloperoxidase and Oxidative MechanismsInflammasome and immune disordersS100 Proteins and Annexins