The role and therapeutic strategies for tissue‐resident memory T cells, central memory T cells, and effector memory T cells in psoriasis
Guoshu Deng, Yulin Zhang, Jiankun Song, Ying Zhang, Qi Zheng, Yue Luo, Yue Luo, Xiaoya Fei, Yang� Yang, Le Kuai, Bin Li, Ying Luo, Ying Luo
Abstract
Psoriasis is a skin disease that is inflammatory and persistent, causing a high rate of recurrence, poor quality of life, and significant socioeconomic burden. Its main pathological manifestations are abnormal activation and infiltration of T cells and excessive proliferation of keratinocytes (KCs). The great majority of patients with psoriasis will relapse after remission. It usually lasts a lifetime and necessitates long-term treatment strategies. During periods of activity and remission, one of the main cell types in psoriasis is memory T cells, which include tissue-resident memory T (TRM) cells, central memory T (TCM) cells, and effector memory T (TEM) cells. They work by releasing inflammatory factors, cytotoxic particles, or altering cell subpopulations, leading to increased inflammation or recurrence. This review summarizes the role of memory T cells in the pathology and treatment of psoriasis, with a view to potential novel therapies and therapeutic targets.