Rational engineering of <i>Acinetobacter tandoii</i> glutamate dehydrogenase for asymmetric synthesis of <scp>l</scp>-homoalanine through biocatalytic cascades
Liuzhu Wang, Shiqing Diao, Yangyang Sun, Shuiqin Jiang, Yan Liu, Hualei Wang, Dongzhi Wei
Abstract
A high yield of <sc>l</sc>-homoalanine can be obtained by an engineered dual cofactor-dependent GluDH in a cascade without the addition of NAD(P)H.
Topics & Concepts
NAD+ kinaseCofactorYield (engineering)ChemistryGlutamate dehydrogenaseCatalysisCascadeDual (grammatical number)BiocatalysisCombinatorial chemistryStereochemistryEnzymeGlutamate receptorBiochemistryMaterials scienceChromatographyReaction mechanismMetallurgyReceptorLiteratureArtEnzyme Structure and FunctionBiochemical and Molecular ResearchEnzyme Catalysis and Immobilization