Disrupting redox homeostasis for tumor therapy based on PDT/chemo/ferroptosis therapeutic hybrid liposomes
Yuanping Huang, Hongsen Liu, Yanfei Zhao, Hao Chen, Qiqing Li, Xiaodan Li, Shucheng Hua, Dianbo Cao, Yulei Chang
Abstract
-mediated Fenton reaction, and DOX-induced apoptosis. Furthermore, amplifying oxidative stress in cancer cells to disrupt cellular redox homeostasis could accelerate tumor cell death through oxidative damage to lipids, proteins, and DNA. Overall, this work highlights liposome-based therapeutic nanoformulations, thus offering a breakthrough redox homeostasis-based synergistic PDT/chemo/ferroptosis therapy for lung cancer.
Topics & Concepts
Photodynamic therapyLiposomeTherapeutic modalitiesCancer researchDrugAdverse effectTherapeutic effectPharmacologyMedicineChemotherapeutic drugsChemistryChemotherapyInternal medicineBiochemistryOrganic chemistryNanoplatforms for cancer theranosticsAdvanced biosensing and bioanalysis techniquesNanoparticle-Based Drug Delivery