Targeted inhibition of branched-chain amino acid metabolism drives apoptosis of glioblastoma by facilitating ubiquitin degradation of Mfn2 and oxidative stress
Zhuo Lü, Guifeng Sun, Kai-Yi He, Zhen Zhang, Xin‐Hao Han, Xin-Hao Han, Xin-Hui Qu, Deng-Feng Wan, Dongyuan Yao, Fangfang Tou, Xiaojian Han, Xiaojian Han, Tao Wang
Topics & Concepts
MFN2PI3K/AKT/mTOR pathwayProtein kinase BMitochondrionOxidative stressBiologyCancer researchApoptosisCell biologyChemistryBiochemistrymitochondrial fusionMitochondrial DNAGeneMitochondrial Function and PathologyAutophagy in Disease and TherapyCancer, Hypoxia, and Metabolism