Design and synthesis of benzylidenecyclohexenones as TrxR inhibitors displaying high anticancer activity and inducing ROS, apoptosis, and autophagy
Jianqiang Qian, Zhongyuan Xu, Chi Meng, Ji Liu, Pei‐Ling Hsu, Yangyang Li, Weizhong Zhu, Yumin Yang, Susan L. Morris‐Natschke, Kuo‐Hsiung Lee, Yanan Zhang, Yong Ling
Topics & Concepts
Thioredoxin reductaseApoptosisChemistryReactive oxygen speciesAutophagyThioredoxinCancer cellIntracellularProgrammed cell deathCancer researchMCF-7Oxidative stressBiochemistryCell biologyCancerPharmacologyBiologyHuman breastGeneticsPiperaceae Chemical and Biological StudiesCholinesterase and Neurodegenerative DiseasesEnzyme function and inhibition