The Intact Noninducible Latent HIV-1 Reservoir Is Established in an <i>In Vitro</i> Primary T <sub>CM</sub> Cell Model of Latency
Indra Sarabia, Szu-Han Huang, Adam R. Ward, R. Brad Jones, Alberto Bosque
Abstract
model of latency using different HIV-1 strains. Thus, the mechanisms which control inducibility can be studied using this primary cell model of latency, which may accelerate our understanding of the latent reservoir and the development of curative strategies.
Topics & Concepts
Virus latencyBiologyAntiretroviral therapyLatency (audio)Human immunodeficiency virus (HIV)Latent VirusIn vitroVirologyImmunologyVirusViral loadViral replicationGeneticsElectrical engineeringEngineeringHIV Research and TreatmentHIV/AIDS drug development and treatmentHIV/AIDS Research and Interventions