Using human genetics to improve safety assessment of therapeutics
Keren Carss, Aimée M. Deaton, Alberto Del Río-Espínola, Dorothée Diogo, Mark R. Fielden, Diptee Kulkarni, Jonathan G. Moggs, Peter Newham, Matthew R. Nelson, Frank D. Sistare, Lucas D. Ward, Jing Yuan
Topics & Concepts
Drug developmentHuman diseaseDrug discoveryDiseaseGenome-wide association studyMendelian inheritanceMedicineHuman genetic variationHuman geneticsComputational biologyHuman genomeRisk analysis (engineering)BioinformaticsDrugBiologyGeneticsPharmacologyGenomeGenePathologySingle-nucleotide polymorphismGenotypePharmaceutical studies and practicesCRISPR and Genetic EngineeringGenomics and Rare Diseases