Natural Inhibitors of P-glycoprotein in Acute Myeloid Leukemia
Manuela Labbozzetta, Paola Poma, Monica Notarbartolo
Abstract
Acute myeloid leukemia (AML) remains an insidious neoplasm due to the percentage of patients who develop resistance to both classic chemotherapy and emerging drugs. Multidrug resistance (MDR) is a complex process determined by multiple mechanisms, and it is often caused by the overexpression of efflux pumps, the most important of which is P-glycoprotein (P-gp). This mini-review aims to examine the advantages of using natural substances as P-gp inhibitors, focusing on four molecules: phytol, curcumin, lupeol, and heptacosane, and their mechanism of action in AML.
Topics & Concepts
Myeloid leukemiaLupeolMultiple drug resistanceP-glycoproteinEffluxCurcuminLeukemiaPharmacologyDrug resistanceMechanism of actionPhytolCancer researchMedicineBiologyChemistryImmunologyBiochemistryIn vitroMicrobiologyDrug Transport and Resistance MechanismsNatural product bioactivities and synthesisNatural Compounds in Disease Treatment