Benzimidates as <i>gem</i>-Diamidation and Amidoindolyzation Cascade Synthons with a Hydrated Ni<sup>II</sup> Catalyst
Rajesh Nandi, Prakash K. Mandal, Anirban Kayet, Tamalika Bhattachariya, Sukla Ghosh, Dilip K. Maiti
Abstract
We contributed a new benzimidate chemistry through moisture-insensitive NiII/NiII-FeIII combo-catalysis for a simultaneous 2–3 bond-forming gem-diamidation and amidoindolyzation cascade reaction to construct symmetrical and unsymmetrical gem-(arylmethylene)amides and indolo(arylmethylene)amides, using emerging benzimidate synthons. The operational simplicity, mild nature, generality, and robustness of the strategy were validated through syntheses of a wide range of new molecules, labile sugar-based chiral compounds, and pharmaceuticals with high yields under the same reaction conditions.
Topics & Concepts
SynthonChemistryCatalysisCascadeCombinatorial chemistryMoleculeOrganic chemistryChromatographyCatalytic C–H Functionalization MethodsSynthesis of Indole DerivativesSynthesis and Catalytic Reactions