Lys-urea-Aad, Lys-urea-Cmc and Lys-urea-Cms as potential pharmacophores for the design of PSMA-targeted radioligands to reduce off-target uptake in kidneys and salivary glands
Hsiou‐Ting Kuo, Zhengxing Zhang, Chengcheng Zhang, Helen Merkens, Ruiyan Tan, Antonio A. W. L. Wong, Carlos Uribe, François Bénard, Kuo‐Shyan Lin
Abstract
Our data demonstrate that that Lys-urea-Aad, Lys-urea-Cmc and Lys-urea-Cms are promising pharmacophores for the design of PSMA-targeted radioligands especially for radiotherapeutic applications to minimize toxicity to kidneys and salivary glands.
Topics & Concepts
UreaLNCaPBiodistributionChemistryPharmacophoreRadioligandLysineBiochemistryPharmacologyAmino acidIn vitroProstate cancerInternal medicineMedicineCancerRadiopharmaceutical Chemistry and ApplicationsProstate Cancer Treatment and ResearchPeptidase Inhibition and Analysis