Spatiotemporally controlled O<sub>2</sub> and singlet oxygen self-sufficient nanophotosensitizers enable the <i>in vivo</i> high-yield synthesis of drugs and efficient hypoxic tumor therapy
Suisui He, Siyu Lu, Sha Liu, Tianrong Li, Jieling Li, Shihao Sun, Meilin Liu, Kun Liang, Fu Xu, Fengjuan Chen, Genping Meng, Lang Zhang, Jun Hai, Baodui Wang
Abstract
A porous photosensitizer displaying catalase-like activity and drug synthesis ability was synthesized for the synergistic chemo-photodynamic therapy, opening new promising ways for carrying out the precise cooperative treatment of hypoxic tumors.
Topics & Concepts
Singlet oxygenIn vivoYield (engineering)OxygenChemistryHypoxia (environmental)Cancer researchCombinatorial chemistryBiophysicsMedicineMaterials scienceBiologyOrganic chemistryBiotechnologyMetallurgyNanoplatforms for cancer theranosticsCancer, Hypoxia, and MetabolismPorphyrin and Phthalocyanine Chemistry