Copper-catalyzed borylative aminomethylation of C–C double and triple bonds with <i>N</i>,<i>O</i>-acetal
Xianfan Qiu, Liugen Xu, Shuxia Wang, Ying Dai, Yunqiu Feng, Chang Gong, Chuanzhou Tao
Abstract
A copper-catalyzed borylaminomethylation of multiple carbon-carbon bonds with N,O-acetal and bis(pinacolato)diboron has been disclosed that offers efficient and expedient access to γ-amino boronates. The products contain a valuable amine and boronate, which are amenable to further elaboration, and have versatile synthetic utilities.
Topics & Concepts
AcetalTriple bondCatalysisCopperChemistryMedicinal chemistryDouble bondStereochemistryPolymer chemistryOrganic chemistryOrganoboron and organosilicon chemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions