Tumor chemical suffocation therapy by dual respiratory inhibitions
Yingying Xu, Yuedong Guo, Lei Chen, Dalong Ni, Ping Hu, Jianlin Shi
Abstract
The EDTA- and Rotenone-loaded MPER nanoparticles have been synthesized to suffocate tumor cells to death through inhibiting glycolytic process and mitochondrial oxidative phosphorylation simultaneously <italic>in vitro</italic> and <italic>in vivo</italic>.
Topics & Concepts
GlycolysisOxidative phosphorylationAdenosine triphosphateMitochondrionGlutathioneBiochemistryEnzymeCitric acid cycleChemistryMetabolic pathwayRotenoneMetabolismBiologyCell biologySupramolecular Chemistry and ComplexesMetal-Organic Frameworks: Synthesis and ApplicationsLanthanide and Transition Metal Complexes