Stage-Specific <i>De Novo</i> Synthesis of Very-Long-Chain Dihydroceramides Confers Dormancy to <i>Entamoeba</i> Parasites
Fumika Mi‐ichi, Kazutaka Ikeda, Hiroshi Tsugawa, Sharmina Deloer, Hiroki Yoshida, Makoto Arita
Abstract
Entamoeba is a protozoan parasite that thrives in its niche by alternating its two forms between a proliferative trophozoite and dormant cyst. Cysts are the only form able to transmit to a new host and are differentiated from trophozoites in a process termed “encystation.” During Entamoeba encystation, cell metabolites, components, and morphology drastically change, which occur sequentially in an orchestrated manner.
Topics & Concepts
Entamoeba histolyticaBiologyCeramideLipid dropletMorphogenesisCell biologyMicrobiologyBiochemistryGeneApoptosisAmoebic Infections and TreatmentsParasitic Infections and DiagnosticsPediatric Hepatobiliary Diseases and Treatments