Effect of citalopram and sertraline on the expression of miRNA- 124, 132, and 16 and their protein targets in patients with depression.
Mahnaz Ahmadimanesh, Leila Etemad, Dorsa Morshedi Rad, Mohammad Hossein Ghahremani, Amir Hooshang Mohammadpour, Reza Jafarzadeh Esfehani, Paul A. Jowsey, Fatemeh Behdani, Seyed Adel Moallem, Mohammad Reza Abbaszadegan
Abstract
Objectives: This study aimed to evaluate the effect of SSRIs on the expression of miRNAs and their protein targets. Materials and Methods: In a 100 day open-label study of citalopram (n=25) and sertraline (n=25), levels of miRNA 16, 132, and 124 and glucocorticoid receptor (GR), Brain-derived neurotrophic factor (BDNF), and serotonin transporter (SERT) protein expression were measured by QRT-PCR and western blot in healthy control (n=20), patients with depression at the baseline, and same patients after 100 days of treatment. Results: 0.05). Conclusion: This elucidated the relationship between antidepressant treatment and the expression of different microRNA that control gene expression in various pathways involved in depressed patients. Receiving SSRI can affect the level of these proteins and their relevant microRNAs.