Norkurarinone and isoxanthohumol inhibit high glucose and hypoxia-induced angiogenesis via improving oxidative stress and regulating autophagy in human retinal microvascular endothelial cells
Kairui Zhao, Yadi Li, Yongyi Qiu, Ruiting Huang, Minling Lin, Lei Chen, Yi Liu
Topics & Concepts
AutophagyPI3K/AKT/mTOR pathwayAngiogenesisOxidative stressRetinalProtein kinase BRetinal pigment epitheliumPharmacologyCell biologyChemistryHypoxia (environmental)Endothelial stem cellApoptosisBiologySignal transductionCancer researchBiochemistryIn vitroOxygenOrganic chemistryBioactive natural compoundsRetinal Diseases and TreatmentsAutophagy in Disease and Therapy