Hippocampal P2X7 and A2A purinoceptors mediate cognitive impairment caused by long-lasting epileptic seizures
Meng-Juan Sun, Wenjing Ren, Yafei Zhao, Xuan Li, Muhammad Tahir Khan, Xinyi Cheng, Haiyan Yin, Alexei Verkhratsky, Tobías Engel, Patrizia Rubini, Yong Tang, Péter Illés
Abstract
SE induced the release of ATP and adenosine from the hippocampus and in consequence decreased the cognitive abilities of mice. The pharmacological blockade of P2X7 and A2ARs prevented the SE-induced seizure activity and cognitive deterioration, but not depressive-like behavior.
Topics & Concepts
Hippocampal formationEpilepsyNeuroscienceCognitive impairmentHippocampusCognitionPsychologyMedicineAdenosine and Purinergic SignalingGenetics and Neurodevelopmental DisordersAmino Acid Enzymes and Metabolism