Iodine-promoted synthesis of pyrazoles from 1,3-dicarbonyl compounds and oxamic acid thiohydrazides
Anna S. Komendantova, Konstantin А. Lyssenko, И. В. Заварзин, Yulia A. Volkova
Abstract
A novel approach to 3,4-dicarbonyl-substituted pyrazoles from 1,3-dicarbonyl compounds and oxamic acid thiohydrazides was developed <italic>via</italic> iodine-promoted cascade imination/halogenation/cyclization/ring contraction reaction.
Topics & Concepts
ChemistryHalogenationIodineMedicinal chemistryRing (chemistry)Organic chemistryStereochemistrySynthesis and biological activitySynthesis and Catalytic ReactionsSynthesis of heterocyclic compounds