Olfactory receptor 78 participates in carotid body response to a wide range of low O<sub>2</sub> levels but not severe hypoxia
Yingjie Peng, Anna Gridina, Benjamin Wang, Jayasri Nanduri, Aaron P. Fox, Nanduri R. Prabhakar
Abstract
The current study demonstrates that olfactory receptor 78 (Olfr78), a G protein-coupled receptor, is an integral component of the hypoxic sensing mechanism of the carotid body to a wide range of low oxygen levels, but not severe hypoxia, and that Olfr78 participation does not require either lactate or any other short-chain fatty acids, proposed ligands of Olfr78.
Topics & Concepts
Carotid bodyHypoxia (environmental)NeuroscienceReceptorChemistryMedicinePsychologyCommunicationInternal medicineElectrophysiologyOxygenOrganic chemistryNeuroscience of respiration and sleepHigh Altitude and HypoxiaEicosanoids and Hypertension Pharmacology