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Repurposing simeprevir, calpain inhibitor IV and a cathepsin F inhibitor against SARS-CoV-2 and insights into their interactions with M <sup>pro</sup>

Abhithaj Jayanandan, Dileep Francis, C. S. Sharanya, Arun K.G., C. Sadasivan, E. Jayadevi Variyar

2020Journal of Biomolecular Structure and Dynamics35 citationsDOI

Abstract

.Communicated by Ramaswamy H. Sarma.

Topics & Concepts

SimeprevirDrugBankVirtual screeningPharmacophoreProtease inhibitor (pharmacology)ProteaseDrug repositioningDocking (animal)Cysteine proteaseRepurposingIn silicoChemistryComputational biologyVirologyBiologyPharmacologyBiochemistryEnzymeVirusViral loadDrugHepatitis C virusMedicineRibavirinAntiretroviral therapyEcologyGeneNursingComputational Drug Discovery MethodsSARS-CoV-2 and COVID-19 ResearchCalpain Protease Function and Regulation
Repurposing simeprevir, calpain inhibitor IV and a cathepsin F inhibitor against SARS-CoV-2 and insights into their interactions with M <sup>pro</sup> | Litcius