Keap1/Nrf2 Signaling Pathway
Gerasimos P. Sykiotis
Abstract
Nuclear factor, erythroid 2-like transcription factor 2 (Nrf2) and its cytoplasmic inhibitor, kelch-like ECH-associated protein 1 (Keap1), comprise a redox-responsive endogenous antioxidant defense module that orchestrates the expression of cytoprotective genes to maintain homeostasis [...].
Topics & Concepts
KEAP1Transcription factorEndogenyCell biologyCytoplasmHomeostasisSignal transductionChemistryBiologyGeneBiochemistryGenomics, phytochemicals, and oxidative stressGlutathione Transferases and Polymorphisms