SGLT2 inhibition effect on salt-induced hypertension, RAAS, and Na<sup>+</sup> transport in Dahl SS rats
Olha Kravtsova, Ruslan Bohovyk, Vladislav Levchenko, Oleg Palygin, Christine A. Klemens, Timo Rieg, Alexander Staruschenko
Abstract
The present study indicates that Na + -glucose cotransporter-2 (SGLT2) inhibition in a nondiabetic model of salt-sensitive hypertension blunts the development and magnitude of salt-induced hypertension. Chronic inhibition of SGLT2 increases glucose and Na + excretion without secondary effects on the expression and function of other Na + transporters and channels along the nephron and hormone levels in the renin-angiotensin-aldosterone system. These data provide novel insights into the effects of SGLT2 inhibitors and their potential use in hypertension.
Topics & Concepts
CotransporterEndocrinologyInternal medicineRenin–angiotensin systemAldosteroneNephronHormoneChemistryTransporterRenal functionSodiumMedicineBiochemistryBlood pressureOrganic chemistryGeneDiabetes Treatment and ManagementDiet, Metabolism, and DiseasePancreatic function and diabetes