Development of bromo- and fluoro-based α, β-unsaturated ketones as highly potent MAO-B inhibitors for the treatment of Parkinson's disease
Mohamed A. Abdelgawad, Jong‐Min Oh, Della Grace Thomas Parambi, Sunil Kumar, Arafa Musa, Mohammed M. Ghoneim, AbdElAziz A. Nayl, Ahmed H. El‐Ghorab, Iqrar Ahmad, Harun Patel, Hoon Kim, Bijo Mathew
Topics & Concepts
ChemistryIC50Monoamine oxidaseStereochemistryInhibitory postsynaptic potentialMonoamine oxidase BDocking (animal)PharmacologyEnzymeIn vitroBiochemistryInternal medicineNursingMedicineParkinson's Disease Mechanisms and TreatmentsElectrochemical sensors and biosensorsClick Chemistry and Applications