Structural basis for non-canonical integrin engagement by Bordetella adenylate cyclase toxin
Jory A. Goldsmith, Andrea M. DiVenere, Jennifer A. Maynard, Jason S. McLellan
Abstract
positions the essential ACT acylation sites, which are conserved among toxins exported by type I secretion systems, at the cell membrane. These findings reveal a structural mechanism for integrin-mediated attachment and explain antibody-mediated neutralization of ACT intoxication.
Topics & Concepts
Adenylate kinaseCyclaseIntegrinToxinChemistryCell biologyAdenylate Cyclase ToxinBasis (linear algebra)MicrobiologyComputational biologyBiochemistryBiologyEnzymeReceptorPertussis toxinG proteinMathematicsGeometryBacterial Infections and VaccinesPeripheral Neuropathies and DisordersMonoclonal and Polyclonal Antibodies Research