Single-cell transcriptomic profiling provides insights into the toxic effects of Zearalenone exposure on primordial follicle assembly
Yu Tian, Mingyu Zhang, Ai‐Hong Zhao, Li Kong, Junjie Wang, Wei Shen, Lan Li
Abstract
This study showed that ZEN affected the status of germ cells and granulosa cells through the Hippo signaling pathway and blocked the assembly of PFs. This research contributes to our deeper understanding of the mechanisms of toxicity in different cell types and the disruption of normal intercellular signaling by ZEN exposure.
Topics & Concepts
BiologyGerm cellImmunostainingCell biologyOvarian follicleFolliculogenesisTranscriptomeBlotAndrologyCellOvaryInternal medicineEndocrinologyImmunologyGene expressionGeneticsEmbryogenesisGeneMedicineEmbryoImmunohistochemistryMolecular Biology Techniques and ApplicationsCancer Cells and MetastasisReproductive Biology and Fertility