Effect of the abolition of intersubunit salt bridges on allosteric protein structural dynamics
Minseo Choi, Jong Goo Kim, Srinivasan Muniyappan, Hanui Kim, Tae Wu Kim, Yunbeom Lee, Sang Jin Lee, Seong Ok Kim, Hyotcherl Ihee
Abstract
The structural and functional roles of salt bridges in the allosteric structural transition of homodimeric hemoglobin are investigated by time-resolved X-ray solution scattering.
Topics & Concepts
Allosteric regulationChemistrySalt (chemistry)Salt bridgeProtein dynamicsStructural changeMolecular dynamicsDynamics (music)BiophysicsHemoglobinCrystallographyComputational chemistryBiochemistryBiologyEnzymePhysicsEconomicsPhysical chemistryGeneAcousticsMutantMacroeconomicsHemoglobin structure and functionProtein Structure and DynamicsSpectroscopy and Quantum Chemical Studies