Direct benzylic C–H difluoroalkylation with difluoroenoxysilanes by transition metal-free photoredox catalysis
Jing Gui, Manman Sun, Haijian Wu, Jinshan Li, Jianguo Yang, Zhiming Wang
Abstract
A visible light promoted direct benzylic C–H difluoroalkylation with difluoroenoxysilanes catalyzed by Na 2 -eosin Y via a HAT-ORPC pathway has been developed, providing an efficient and atom-economic method for production of α-benzyl-α,α-difluoroketones.
Topics & Concepts
ChemistryEosin YPhotoredox catalysisCatalysisTransition metalPhotochemistryVisible spectrumAtom (system on chip)Combinatorial chemistryMedicinal chemistryPhotocatalysisOrganic chemistryOptoelectronicsPhysicsComputer scienceEmbedded systemFluorine in Organic ChemistryRadical Photochemical ReactionsInorganic Fluorides and Related Compounds