Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis
Zu‐Guo Zheng, Yin-Yue Xu, Wenping Liu, Yang Zhang, Chong Zhang, Han-Ling Liu, Xiaoyu Zhang, Run‐Zhou Liu, Yiping Zhang, Meng-Ying Shi, Hua Yang, Ping Li
Topics & Concepts
Insulin resistanceDiacylglycerol kinaseActivator (genetics)Protein kinase CInsulin receptorPharmacologyAllosteric regulationEndocrinologyAMPKSignal transductionInternal medicineLipid metabolismKinaseChemistryInsulinProtein kinase ABiologyBiochemistryMedicineReceptorMetabolism, Diabetes, and CancerProtein Kinase Regulation and GTPase SignalingAdipose Tissue and Metabolism