Cortical microglia dynamics are conserved during voluntary wheel running
Alexandra O. Strohm, Thomas N. O’Connor, Sadie Oldfield, Sala Young, Christian Hammond, Matthew N. McCall, Robert T. Dirksen, Ania K. Majewska
Abstract
We demonstrate the first use of chronic in vivo imaging of microglia over time during physical exercise. We found that microglia movement, morphology, and process motility were remarkably stable during voluntary wheel running (VWR). Additionally, microglia in running mice respond similarly to laser ablation injury compared to sedentary mice. These findings indicate that VWR does not induce changes in microglia dynamics in healthy adults. Exercise may elicit positive effects on the brain through other mechanisms.
Topics & Concepts
MicrogliaMotilityWheel runningNeuroscienceIn vivoDynamics (music)TurnoverBiologyMedicinePhysical medicine and rehabilitationPsychologyInternal medicineEndocrinologyInflammationCell biologyManagementPedagogyEconomicsBiotechnologyNeuroinflammation and Neurodegeneration MechanismsOlfactory and Sensory Function StudiesAdipose Tissue and Metabolism