Association of High-Density Lipoprotein Cholesterol With GFR Decline in a General Nondiabetic Population
Toralf Melsom, Jon Viljar Norvik, Inger Therese Enoksen, Vidar T.N. Stefansson, Renathe Rismo, Trond Jenssen, Marit D. Solbu, Björn O. Eriksen
Abstract
INTRODUCTION: Although lower high-density lipoprotein cholesterol (HDL-C) levels are considered a risk factor for cardiovascular disease (CVD), experimental evidence suggest that aging, inflammation, and oxidative stress may remodel HDL-C, leading to dysfunctional HDL-C. Population studies on HDL-C and loss of the glomerular filtration rate (GFR) reported inconsistent results, but they used inaccurate estimates of the GFR and may have been confounded by comorbidity. METHODS: =1324) after a median of 5.6 years. We also investigated any possible effect modification by low-grade inflammation, physical activity, and sex. RESULTS: < 0.001] per doubling in HDL-C). Effect modifications indicated a stronger association between high HDL-C and GFR loss in physically inactive persons, those with low-grade inflammation, and men. CONCLUSION: Higher HDL-C levels were independently associated with accelerated GFR loss in a general middle-aged nondiabetic population.