Effect of the glucocorticoid receptor antagonist PT150 on acquisition and escalation of fentanyl self-administration following early-life stress.
Michael T. Bardo, Cassie M. Chandler, Emily D. Denehy, Benjamin Carper, Mark Prendergast, Tracy L. Nolen
Abstract
intake in females, thus negating the sex difference. Although PT150 may serve as an effective treatment for reducing the risk of OUD following early-life stress in males, further work is needed to determine the mechanism underlying the differential effects of PT150 in males and females. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
Topics & Concepts
AntiglucocorticoidPlaceboGlucocorticoidSelf-administrationCorticosteroneMedicineGlucocorticoid receptorPsychologyInternal medicineAntagonistFentanylEndocrinologyReceptor antagonistAnesthesiaReceptorHormonePathologyAlternative medicineStress Responses and CortisolNeuroendocrine regulation and behaviorAnesthesia and Neurotoxicity Research