PRMT5-dependent transcriptional repression of c-Myc target genes promotes gastric cancer progression
Ming Liu, Bing Yao, Tao Gui, Chan Guo, Xiaobin Wu, Jiahuang Li, Lingling Ma, Yexuan Deng, Peipei Xu, Ying Wang, Dongjun Yang, Qi‐Xiang Li, Xiangwei Zeng, Xinyu Li, Ruifeng Hu, Jingru Ge, Zenong Yu, Yugen Chen, Chen Bing, Junyi Ju, Quan Zhao
Abstract
: Taken together, our study reveals a novel mechanism by which PRMT5-dependent transcriptional repression of c-Myc target genes is required for gastric cancer progression, and provides a potential new strategy for therapeutic targeting of gastric cancer.
Topics & Concepts
Protein arginine methyltransferase 5Chromatin immunoprecipitationPsychological repressionBiologyCancer researchOncogeneGeneGene expressionRegulation of gene expressionPromoterCancerMolecular biologyMethyltransferaseMethylationCell cycleGeneticsCancer-related gene regulationEpigenetics and DNA Methylation