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Optimal control strategies for the transmission risk of COVID-19

Legesse Lemecha Obsu, Shiferaw Feyissa Balcha

2020Journal of Biological Dynamics94 citationsDOIOpen Access PDF

Abstract

In this paper, we apply optimal control theory to a novel coronavirus (COVID-19) transmission model given by a system of non-linear ordinary differential equations. Optimal control strategies are obtained by minimizing the number of exposed and infected population considering the cost of implementation. The existence of optimal controls and characterization is established using Pontryagin's Maximum Principle. An expression for the basic reproduction number is derived in terms of control variables. Then the sensitivity of basic reproduction number with respect to model parameters is also analysed. Numerical simulation results demonstrated good agreement with our analytical results. Finally, the findings of this study shows that comprehensive impacts of prevention, intensive medical care and surface disinfection strategies outperform in reducing the disease epidemic with optimum implementation cost.

Topics & Concepts

Optimal controlTransmission (telecommunications)Basic reproduction numberMaximum principlePontryagin's minimum principleOrdinary differential equationSensitivity (control systems)MathematicsMathematical optimizationPopulationEpidemic modelCoronavirus disease 2019 (COVID-19)Control theory (sociology)Control (management)Applied mathematicsComputer scienceDifferential equationEngineeringDiseaseMedicineArtificial intelligenceInfectious disease (medical specialty)Mathematical analysisElectronic engineeringTelecommunicationsEnvironmental healthPathologyCOVID-19 epidemiological studiesMathematical and Theoretical Epidemiology and Ecology ModelsSARS-CoV-2 and COVID-19 Research
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