Hypermethylation of GNA14 and its tumor-suppressive role in hepatitis B virus-related hepatocellular carcinoma
Guangyuan Song, Xingxin Zhu, Zefeng Xuan, Long Zhao, Haijiang Dong, Jian Chen, Zequn Li, Wenfeng Song, Cheng Jin, Mengqiao Zhou, Haiyang Xie, Shusen Zheng, Penghong Song
Abstract
: GNA14 could be regulated by HBx by modulating the methylation status of its promoter. We identified GNA14 as a potential biomarker and therapeutic target for HCC.
Topics & Concepts
Hepatocellular carcinomaDNA methylationHepatitis B virusCancer researchVirologyVirusMedicineHepatitis C virusPathologyBiologyGeneGeneticsGene expressionEpigenetics and DNA MethylationHepatitis B Virus StudiesCancer-related gene regulation