Ergothioneine exhibits longevity-extension effect in <i>Drosophila melanogaster via</i> regulation of cholinergic neurotransmission, tyrosine metabolism, and fatty acid oxidation
Hongyu Pan, Zhiwei Ye, Qianwang Zheng, Fan Yun, Ming-Zhen Tu, Weiguo Hong, Bai‐Xiong Chen, Li‐Qiong Guo, Jun‐Fang Lin
Abstract
the coordination of cholinergic neurotransmission, tyrosine metabolism, and peroxisomal proteins, regulation of autophagic activity by altering the lysosomal protein CTSD, and the preservation of normal mitochondrial function through controlled substrate feeding into the tricarboxylic acid (TCA) cycle, the major energy-yielding metabolic process in cells.
Topics & Concepts
Drosophila melanogasterErgothioneineLongevityCholinergicTyrosineMetabolismBiochemistryChemistryFatty acidNeurotransmissionLipid metabolismDYRK1ABeta oxidationCell biologyBiologyEndocrinologyGeneticsReceptorGeneAntioxidantCholinesterase and Neurodegenerative DiseasesGenetics, Aging, and Longevity in Model OrganismsTryptophan and brain disorders