Pre-Operative Predictors for Post-Operative Pneumonia in Aneurysmal Subarachnoid Hemorrhage After Surgical Clipping and Endovascular Coiling: A Single-Center Retrospective Study
Kexin Yuan, Runting Li, Yahui Zhao, Yahui Zhao, Ke Wang, Fa Lin, Junlin Lu, Yú Chen, Li Ma, Heze Han, Debin Yan, Ruinan Li, Jun Yang, Shihao He, Zhipeng Li, Haibin Zhang, Xun Ye, Hao Wang, Hongliang Li, Linlin Zhang, Guangzhi Shi, Jianxin Zhou, Yang Zhao, Yang Zhao, Yukun Zhang, Youxiang Li, Shuo Wang, Xiaolin Chen, Yuanli Zhao, Yuanli Zhao, Qiang Hao
Abstract
Objective Postoperative pneumonia (POP) is one of the major complications after aneurysmal subarachnoid hemorrhage (aSAH) associated with postoperative mortality, prolonged hospitalization, and increased medical cost. Early recognition of pneumonia and more aggressive management may improve patient outcomes. Methods We retrospectively reviewed all patients with aSAH who were admitted to our institution between January 2015 and December 2020. Baseline clinical characteristics, imaging data, and inflammatory biomarkers were reviewed. The risk factors derived from multivariate logistic regression of surgical clipping (SC) and endovascular coiling (EC) were analyzed. The area under the receiver operating characteristic (ROC) curve (AUC) was used to calculate each independent predictor's prediction ability. Results A total of 843 patients were enrolled. Compared with patients in the EC group, the incidence of POP was higher in the SC group [143/414 (34.54%) vs. 114/429 (26.57%), p = 0.015]. In the EC group, multivariate analysis revealed that age [ p = 0.001; odds ratio (OR) = 1.04, 95% CI = 1.02–1.07], posterior circulation aneurysms ( p = 0.021; OR = 2.07, 95% CI = 1.14–3.83), higher neutrophil (NEUT; p < 0.001; OR = 1.13, 95% CI = 1.06–1.21), World Federation of Neurosurgical Societies (WFNS) grade 4 or 5 ( p < 0.001; OR = 4.84, 95% CI = 2.67–8.79), modified Fisher Scale (mFS) grade 3 or 4 ( p = 0.022; OR = 2.60, 95% CI = 1.15–5.89), and acute hydrocephalus ( p = 0.048; OR = 1.74, 95% CI = 1.01–3.00) were independent risk factors for POP. In the SC group, multivariate analysis revealed that age ( p = 0.015; OR = 1.03, 95% CI = 1.01–1.05), WFNS grade 4 or 5 ( p = 0.037; OR = 1.76, 95% CI = 1.03–3.00), heart disease ( p < 0.001; OR = 5.02, 95% CI = 2.03–12.45), higher white blood cell (WBC; p < 0.001; OR = 1.13, 95% CI = 1.07–1.20), and mFS grade 3 or 4 ( p = 0.019; OR = 2.34, 95% CI = 1.15–4.77) were independent risk factors for POP. Conclusion Patients treated with SC are more likely to develop POP. Comprehensive preoperative evaluation of patients may help physicians to better predict POP and implement preventive measures to improve outcomes.