Mitophagy, Ferritinophagy and Ferroptosis in Retinal Pigment Epithelial Cells Under High Glucose Conditions: Implications for Diabetic Retinopathy and Age-Related Retinal Diseases.
Lalit P. Singh, Thangal Yumnamcha, Takhellambam S. Devi
Abstract
cultures to highlight some of the intricacies of these cellular processes, which may be relevant to the pathogenesis of DR and age-related retinal neurodegenerative diseases, such as age-related macular degeneration, AMD.
Topics & Concepts
MitophagyDiabetic retinopathyAutophagyOxidative stressRetinalMacular degenerationLysosomeGPX4GlutathionePhospholipid-hydroperoxide glutathione peroxidaseProgrammed cell deathRetinal pigment epitheliumLipid peroxidationChemistryBiologyMedicineDiabetes mellitusApoptosisInternal medicineEndocrinologyGlutathione peroxidaseBiochemistryOphthalmologyCatalaseEnzymeHeme Oxygenase-1 and Carbon MonoxideRetinal Diseases and TreatmentsConnexins and lens biology