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Fluorenyl-phthalimide hybrids as potent aldose reductase inhibitors with selective anticancer activity: Rational design, synthesis, and molecular insights

Saliha Gündoğdu, Hatice Esra Duran, Mustafa Arslan, Büşra Demir Çetinkaya, Cüneyt Türkeş

2025Bioorganic Chemistry50 citationsDOI

Topics & Concepts

ChemistryAldose reductasePhthalimideRational designAldose reductase inhibitorBiochemistryCombinatorial chemistryStereochemistryEnzymeNanotechnologyMaterials scienceAldose Reductase and TaurineEnzyme function and inhibitionInflammatory mediators and NSAID effects
Fluorenyl-phthalimide hybrids as potent aldose reductase inhibitors with selective anticancer activity: Rational design, synthesis, and molecular insights | Litcius