Covalently Conjugated NOD2/TLR7 Agonists Are Potent and Versatile Immune Potentiators
Samo Guzelj, Matjaž Weiss, Bram Slütter, Ruža Frkanec, Žiga Jakopin
Abstract
, with a Th1-polarized profile. Importantly, our study shows that novel NOD2/TLR7 agonists elicit sophisticated and fine-tuned immune responses that are inaccessible to individual NOD2 and TLR7 agonists.
Topics & Concepts
TLR7Immune systemPotentiatorChemistryNOD2ReceptorAdjuvantCell biologyPharmacologyImmunologyToll-like receptorBiochemistryBiologyInnate immune systemImmune Response and InflammationImmunotherapy and Immune ResponsesImmune Cell Function and Interaction