Riplet Binds the Zinc Finger Antiviral Protein (ZAP) and Augments ZAP-Mediated Restriction of HIV-1
Marlene V. Buckmaster, Stephen P. Goff
Abstract
The ZAP is a potent restriction factor inhibiting replication of many RNA viruses by binding directly to viral RNAs and targeting them for degradation. We here identify RIPLET as a cofactor that stimulates ZAP activity. The finding connects ZAP to other innate immunity pathways and suggests oligomerization as a common theme in sensing pathogenic RNAs.
Topics & Concepts
BiologyZinc fingerAntiviral proteinHuman immunodeficiency virus (HIV)ZincVirologyCell biologyGeneticsRNATranscription factorGeneMetallurgyMaterials scienceinterferon and immune responsesHIV Research and TreatmentRNA Research and Splicing