Longitudinal Assessment of SARS-CoV-2-Specific T Cell Cytokine-Producing Responses for 1 Year Reveals Persistence of Multicytokine Proliferative Responses, with Greater Immunity Associated with Disease Severity
Jonah Lin, Ryan Law, Chapin S. Korosec, Christine Zhou, Wan Hon Koh, Mohammad Sajjad Ghaemi, Philip Samaan, Hsu Kiang Ooi, Vitaliy Matveev, FengYun Yue, Anne‐Claude Gingras, Antonio Estacio, Megan Buchholz, Patti Lou Cheatley, Avid Mohammadi, Rupert Kaul, Katerina Pavinski, Samira Mubareka, Allison McGeer, Jerome A. Leis, Jane M. Heffernan, Mario Ostrowski
Abstract
Our findings highlight the relative importance of SARS-CoV-2-specific GzmB-producing T cell responses in SARS-CoV-2 control and shared CD4 and CD8 immunodominant epitopes in seasonal coronaviruses or SARS-CoV-1, and they indicate robust persistence of T cell memory at least 1 year after infection. Our findings should inform future strategies to induce T cell vaccines against SARS-CoV-2 and other coronaviruses.