Regulation of bone metabolism mediated by β-adrenergic receptor and its clinical application
Zhong Xue-Ping, Wenfang Xia
Abstract
Recent studies have confirmed that β-adrenergic receptors (β-ARs) are expressed on the surface of osteoblasts and osteoclasts, and that the sympathetic nervous system can regulate bone metabolism by activating them. β-AR blockers (BBs) are commonly used in the treatment of cardiovascular diseases in the elderly. It is important to investigate whether BBs have a beneficial effect on bone metabolism in the treatment of cardiovascular diseases, so as to expand their clinical application. This article reviews the effects of BB on bone metabolism and the progress of clinical research.
Topics & Concepts
MedicineBone remodelingReceptorSympathetic nervous systemAdrenergicMetabolismAdrenergic receptorInternal medicineEndocrinologyBioinformaticsBlood pressureBiologyHormonal Regulation and HypertensionNeuropeptides and Animal PhysiologyAnesthesia and Sedative Agents