A mitochondrial-metabolism-regulatable carrier-free nanodrug to amplify the sensitivity of photothermal therapy
Qian Du, Xiaohan Qin, Mengzhu Zhang, Zhipeng Zhao, Qian Li, Xiaomeng Ren, Ningning Wang, Yuxia Luan
Abstract
The oxidative phosphorylation inhibitor atovaquone (ATO) and the photosensitizer new indocyanine green (IR820) were self-assembled into carrier-free nanodrugs (IR820/ATO NPs) to achieve superior photothermal therapy (PTT), offering an attractive mitochondrial metabolism-regulatable approach for breast cancer treatment, where adenosine triphosphate (ATP) was downregulated along with downregulating the expression of heat shock proteins (HSPs) to amplify the sensitivity of PTT.
Topics & Concepts
Photothermal therapyAdenosine triphosphateChemistryPhotosensitizerOxidative phosphorylationHeat shock proteinPhosphorylationBiophysicsHsp27Photodynamic therapyCell biologyBiochemistryNanotechnologyBiologyMaterials scienceHsp70PhotochemistryGeneOrganic chemistryNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisExtracellular vesicles in disease