Nuclear genome-wide associations with mitochondrial heteroplasmy
Priyanka Nandakumar, Chao Tian, Jared O’Connell, David A. Hinds, Andrew D. Paterson, Neal Sondheimer
Abstract
), which has multiple roles in mtDNA packaging, replication, and transcription. These results show that mitochondrial heteroplasmy has a heritable nuclear component.
Topics & Concepts
HeteroplasmyMitochondrial DNAHaplogroupGeneticsBiologyGenomeHuman mitochondrial geneticsTFAMNuclear geneHaplotypeAlleleGeneMitochondrial Function and PathologyRNA modifications and cancerMetabolism and Genetic Disorders