A review on the sulfur ylide-mediated Corey–Chaykovsky reaction: a powerful approach to natural product synthesis
Ammara Ammara, Asim Mansha, Samreen Gul Khan, Ameer Fawad Zahoor, Muhammad Jawwad Saif, Bushra Parveen, Muhammad Saeed, Aijaz Rasool Chaudhry, Ahmad Irfan, Muhammad Nadeem Abbas
Abstract
a sulfur ylide-mediated process. The reaction enables a simple yet versatile strategy to access cyclopropanes, epoxides and aziridines. The resulting cyclic frameworks are significantly valuable for the synthesis of several structurally complex compounds, including numerous natural products and their analogues. This review underscores the importance and utility of the Corey-Chaykovsky reaction towards the total synthesis of several classes of natural products reported since 2020.
Topics & Concepts
SulfurNatural productChemistryBiochemical engineeringOrganic synthesisOrganic chemistryCombinatorial chemistryNatural (archaeology)Product (mathematics)Reaction conditionsSimple (philosophy)Production (economics)Final productComputer scienceAsymmetric Synthesis and CatalysisChemical synthesis and alkaloidsCyclopropane Reaction Mechanisms