Electroreductive Nickel-Catalyzed Allylation of Aryl Chlorides
Xin Fu, Tingting Ran, Yu Zhou, Jie Liu
Abstract
Herein, we report a facile and efficient allylation via electrochemical promoted Ni-catalyzed reductive carbon-carbon bond formation. Readily available (hetero)aryl chlorides with a variety of allylic sulfones are used as electrophiles in this electroreductive coupling. This Ni-catalyzed modular approach displays generally good functional group tolerance and broad substrate scope. This reaction allows a series of allylic compounds to be created including several structurally complex natural products and pharmaceutical motifs.
Topics & Concepts
Allylic rearrangementElectrophileArylCatalysisChemistryCombinatorial chemistryNickelElectrochemistrySubstrate (aquarium)Functional groupOrganic chemistryAlkylElectrodePolymerGeologyOceanographyPhysical chemistrySulfur-Based Synthesis TechniquesRadical Photochemical ReactionsCatalytic C–H Functionalization Methods